Hanger believes the idea of castration is not at all radical and will get at the root the a sexual predator's drive to assault get more multisource video news analysis from newsy newsydotcom subscribe unsubscribe 37. Objective to clinically assess in a prospectively defined analysis plan of a clinical trial the automated bone scan index (absi) as an independent prognostic determinant of overall survival (os) in men with metastatic castration-resistant prostate cancer (mcrpc. Chemical castration and physical castration - a critical analysis of the effects of chemical castration and physical castration on the recidivism rates of sex offenders introduction this paper examines the effects of chemical castration and physical castration on the recidivism rates of sex offenders.
The neurotic protests against castration, the sacrifice to be made, retaining the demand for the phallus, the major focus of the whole imaginary play in the analysis of a subject for a woman, penis envy and the demand to the analyst to compensate for her lack is ever present. Scrotal castration was comparable with traditional prescrotal castration in terms of incidence of most postoperative complications however, the scrotal method was associated with less self-trauma scrotal castration also offered an approximately 30% faster surgery time. Castration anxiety is the fear of emasculation in both the literal and metaphorical sense castration anxiety is an overwhelming fear of damage to, or loss of , the penis one of sigmund freud 's earliest psychoanalytic theories [1. Analysis of records of court eunuchs in korea suggest that castration prolongs life does it really, or are there other explanations documents detailing the lives of 81 eunuchs who lived in korea.
This post hoc analysis of the pivotal cou-aa-302 study shows that abiraterone acetate plus prednisone significantly improves outcomes in patients with metastatic castration-resistant prostate cancer regardless of baseline characteristics. Management of castration-resistant prostate cancer with oligometastases (pcs ix) the safety and scientific validity of this study is the responsibility of the study sponsor and investigators listing a study does not mean it has been evaluated by the us federal government. We conducted a retrospective analysis of a combined dataset of these trials in an attempt to identify a benefit in subsets of patients based on prognostic risk factors methods: baseline characteristics and survival data were combined for comet-1 and comet-2. Androgen deprivation is the mainstay of advanced prostate cancer treatment despite initial responses, almost all patients progress to castration-resistant prostate cancer (crpc) the. In totem and taboo (1912-13a), freud presented the myth that he believed was the basis of human socialization the threat of castration and the murder of the father were themes present in freud's writings in this vein throughout his work, concluding with moses and monotheism (1939a.
Fizazi k, scher hi, molina a, et al abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the cou-aa-301 randomised, double. Castration anxiety castration anxiety or complex is what makes the oedipal stage of development, as described by sigmund freud, so intolerable in freudian analysis there are only two complexes, the castration complex and the oedipal complex. Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets sari toropainen , 1 einari a niskanen , 1 marjo malinen , 1 päivi sutinen , 1 minna u kaikkonen , 2 and jorma j palvimo a, 1. Original article cost-savings analysis of ar-v7 testing in patients with metastatic castration-resistant prostate cancer eligible for treatment with abiraterone or enzalutamide. Castration is a lively history of the meaning, function, and act of castration from its place in the early church to its secular reinvention in the renaissance as a spiritualized form of masculinity in its 20th century position at the core of psychoanalysis.
In this prespecified exploratory analysis, we compared the patient-reported outcomes of hrqol in men with high-risk, non-metastatic castration-resistant prostate cancer treated with apalutamide plus androgen deprivation therapy, versus those of men treated with placebo plus androgen deprivation therapy. After a median follow-up of 304 months at a planned interim analysis (after 406 pa- abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer. Results after partially completed surveys and missing data were omitted, 189 responses were included in the analysis surgical castration with a scalpel followed by testicular removal by twisting (calves 90 kg) was the most common method of castration used. A follow-up analysis from the pr-7 trial, in men with biochemically recurrent prostate cancer, found that lower testosterone levels were predictive of improved cancer-specific survival and time to castration-resistant prostate cancer (crpc) 17 these studies suggested that deeper androgen blockade could improve clinical outcomes for patients. Methods we performed a retrospective analysis of data acquired from the recently published netherlands prostate study (nepro) to evaluate the influence of advanced age on docetaxel therapy in elderly men (70 years) with castration resistant prostate cancer (crpc) and bone metastases.
Faulkner's sense of bawdy humor is apparent in this scene as he has benjy remembering his castration, luster trying to sell the golf ball, and the golfer sadistically taking the ball from luster by force — just as benjy's testicles were taken from him without sufficient motivation. Castration can occur by accident (eg war injuries, pelvic crushing from auto accidents, severe burns, etc), as a form of torture, punishment, or self-mutilation, or be the result of surgery, perhaps for a medical condition such as testicular cancer or prostate cancer. Castrate - a man who has been castrated and is incapable of reproduction eunuchs guarded the harem eunuch adult male , man - an adult person who is male (as opposed to a woman) there were two women and six men on the bus. In short, taylor's analysis of the history and purposes of castration sheds less light on the cultural construct of masculinity than on the sadistic sexual abuse and humiliation with which males can be threatened and subjugated.
Background molecular characterization of tumors could be a key to therapeutic decision-making with regards to targeted therapies in castration-resistant prostate cancer (crpc. The among-the-trial heterogeneity was assessed using a qualitative methodological and clinical analysis results: four trials were selected in three trials, the comparator was placebo, in one trial it was mitoxantrone, the effect of which in improving survival was considered negligible.